Somewhere along the line this became marketing: not much equipoise in ACHIEVE, MIRACLE, PROMISE, or IMPROVE-IT, eh? A study has classified this as a form of coercion. Ivan Oransky called for a HALT (Help Acronyms Leave Trials). If you're irritated by the next outbreak of trial acronymania or acronymesis you come across, you're not alone!
Another trial acronym here at Statistically Funny.....Meet the AGHAST Investigators!
(Updated with IMPROVE-IT on 16 July 2019.)